Compound nutrient assisted phototherapy in the treatment of neonatal jaundice: a multicenter clinical study
10.3760/cma.j.issn.1673-4408.2018.07.014
- VernacularTitle:复合营养素辅助光疗治疗新生儿黄疸的多中心临床研究
- Author:
Bing WEI
1
;
Dongmei YUE
;
Chuanzhe CHEN
;
Shimeng ZHAO
;
Xian CHENG
;
Yuwu SU
;
Zhixia LIANG
;
Zhihua WANG
;
Kelun WEI
Author Information
1. 沈阳军区总医院儿科
- Keywords:
High indirect bilirubin;
Term newborn;
Compound nutrient;
Phototherapy
- From:
International Journal of Pediatrics
2018;45(7):551-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the curative effect of compound nutrient assisted phototherapy on neonatal jaundice.Methods Neonatologists at seven hospitals participated in the study.A total of three hundred and twenty full-term newborns with high indirect bilirubin admitted to hospital from September 2017 to January 2018 were selected.One hundred and sixty-six cases in the observation group,and one hundred and fifty-four cases in the control group,all enrolled neonates were given single-sided,conventional intensity phototherapy.Observation group took compound nutrient at the same time.The average gestational age,age,birth weight of two groups before treatment were not significantly different.Serum total biilirubin,indirect bidirubin,liver function (ALT,AST) and phototherapy time were monitored before treatment and 3 days after treatment.Results The serum total bilirubin in the observation group was significantly lower than that of the control group after 3 days of treatment[(196.7 ± 57.2) μmol/L vs (216.5 ± 54.6) μmol/L],(t=3.17,P＜0.01).The indirect bilirubin in the observation group was significantly lower than that of the control group after 3 days of treatment [(176.3 ± 54.3) μmol/L vs (197.2 ± 52.9) μmol/L],(t=3.50,P＜0.01).The time of phototherapy of the children in the observation group was significantly shorter than that of the control group[(19.8 ± 14.4)d vs (22.9 ± 13.3) d],(t =2.00,P ＜ 0.01).Rash,fever,bronze disease,spilled milk,vomiting,abdominal distention,diarrhea,constipation,liver damage etc.were no significant difference the observation group and the control group(P ＞ 0.05).Conclusion Compound nutrients had good efficacy and safety in adjuvant phototherapy for neonatal high indirect bidirubin.
