Toll-like receptors in B cell activation and STAT3 signal pathway
10.3760/cma.j.issn.1673-4408.2018.05.015
- VernacularTitle:Toll样受体对B细胞的激活作用与STAT3信号通路的关系
- Author:
Ruolan GONG
1
Author Information
1. 上海交通大学医学院附属上海儿童医学中心过敏免疫科
- Keywords:
TLR;
TLR9;
B cell functions;
STAT3;
Hyper-IgE syndrome
- From:
International Journal of Pediatrics
2018;45(5):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors(TLR) are widely exist in antigen presenting cells as a kind of pattem recognition receptor involved in the recognition of molecular structures specific for microbial pathogens,and have an important effect on innate and adaptive immune responses.There are 10 types of TLR in human beings which can be grouped into two main categories:cell surface receptors and receptors localized in the endosome.Among all the TLRs,TLR7 and TLR9,which expressed widely in human B cells,are important to B cells' functions.Two signal transduction pathways of TLR including MyD88 pathway and non-MyD88 pathway associate with B cells activation,proliferation,differentiation and antibody secretion.TLR7 and TLR9's stimulus,such as CpG-containing oligodeoxynucleotides(ODN) can activate memory B cells and naive B cells,promote cells proliferation,plasma cells generation,cytokine secretion and protect them from apoptosis.More than that,TLR7 and TLR9 can stimulate the production of IgG and IgM,make antibody shift to IgG2a and block the production of IgG1 and IgE.Interestingly,TLR-MyD88 pathway is recently confirmed to have connection with STAT3 signal pathway.However,the mutation of STAT3 will cause autosomal dominant hyper-IgE syndrome (HIES),a primary immunodeficiency characterized by elevated IgE levels,eczema,recurrent infections,pneumonia as well as multi-system symptoms.Therefore,the pathogenesis of HIES maybe related to the inhibition of TLR-MyD88-STAT3 signal pathway.As a result,we write a review about TLR in B cell activation and STAT3 signal pathway,and discuss their connection between HIES.
