Role of tryptophan catabolism in pediatric allergic diseases
10.3760/cma.j.issn.1673-4408.2018.02.021
- VernacularTitle:色氨酸分解代谢与儿童过敏性疾病
- Author:
Shimin ZHONG
1
Author Information
1. 陆军军医大学第一附属医院儿科
- Keywords:
Tryptophan metabolism;
Allergic diseases
- From:
International Journal of Pediatrics
2018;45(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
With the change of environment and life-style,the incidence of allergic diseases in children is increasing,but its pathogenesis is not entirely elucidated.It is shown that tryptophan catabolism mediated by indoleamine 2,3-dioxygenase plays a significant role in the pathophysiology of allergic diseases of children such as asthma and allergic rhinitis.These roles include inducing Treg cell,inhibiting Th2 cell response,mediating immune tolerance and so forth.Therefore,it is a new target for the prevention and treatment of allergic diseases by stimulating the immune cells and changing the diet structure to regulate tryptophan catabolism.This article reviews the role of tryptophan decomposition in children allergic diseases.
