Oxidative stress and coronary artery lesions in Kawasaki disease
10.3760/cma.j.issn.1673-4408.2018.02.004
- VernacularTitle:氧化应激与川崎病冠状动脉病变
- Author:
Hongyu KUANG
1
Author Information
1. 400014,重庆医科大学附属儿童医院心血管内科
- Keywords:
Kawasaki disease;
Coronary artery lesion;
Oxidative stress;
Antioxidant pharmacotherapy
- From:
International Journal of Pediatrics
2018;45(2):84-87
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease(KD) is an acute systemic vasculitis that most commonly involves coronary artery.It is one of the leading causes of acquired heart diseases,but with an unclear mechanism.At present,in the pathological progress of cardiovascular diseases,oxidative stress (OS) has been demonstrated to play an important role.It damages the function of intravascular endothelial cells and weakens the structure of subendothelial layer and tunica media,reducing vascular elasticity and leading to long-term cardiovascular events.In KD patients,it has been believed that OS is likely to be involved in the pathogenesis of coronary artery lesion.Hence,based on the latest studies about KD,this paper reviewed the role of OS in pathophysiological mechanisms of vascular endothelial dysfunction,the possibility of antioxidant pharmacotherapy as a prevention from coronary artery lesion.
