NLRP12 and its role in occurrence and development of diseases
10.3760/cma.j.issn.1673-4408.2018.01.004
- VernacularTitle:NLRP12及其在疾病发生和发展中的作用
- Author:
Linqing ZHONG
1
Author Information
1. 100730,中国医学科学院北京协和医学院北京协和医院儿科
- Keywords:
NOD-like receptors family pyrin domain containing 12;
Inflammasome;
Function
- From:
International Journal of Pediatrics
2018;45(1):13-16
- CountryChina
- Language:Chinese
-
Abstract:
NLRP12 is a member of the NOD-like receptors family in innate immune system,and plays an important role on resistance to intracellular pathogens.Once being activated,NLRP12 could recruit and combine with its downstream effector proteins into inflammasome,thus involving in pathogen clearance.Meanwhile,NLRP12 is one of the several anti-inflammatory molecules in the NOD-like receptors family.In this review,its structure,tissue distribution,function and association with diseases were discussed.
