Assessment of Height Prediction Model Based on SNPs Loci
10.3969/j.issn.1004-5619.2018.02.005
- VernacularTitle:基于SNP位点的身高预测模型的评估
- Author:
Hui-Yong JIAO
1
;
Ya-Nan SUN
;
Xiao-Xi JING
;
Jing LIU
;
Li JIANG
;
Cai-Xia LI
;
Jian YE
;
Fan LIU
;
Yan-Mei HUANG
;
Wen-Ting ZHAO
Author Information
1. 新乡医学院法医学系
- Keywords:
forensic genetics;
forensic anthropology;
single nucleotide polymorphism;
body height;
fore-casting;
Han nationality
- From:
Journal of Forensic Medicine
2018;34(2):132-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a height prediction model of Chinese Han male based on the reported 547 height-associated single nucleotide polymorphisms (SNPs) loci in Europeans, and assess its accuracy for height estimation. Methods The DNA typing was analyzed in 59 Han male samples of Shandong province by Affymetrix SNP Array 6.0 chip and HiSeq 4000 sequencing platform. Prediction model was established using 547 height-associated SNPs loci as predictors and weight allele sums (WAS) as com-puting method. The accuracy of height prediction model was analysed using receiver operating characteris-tic (ROC) curve and area under curve (AUC). Results There was no height-associated SNPs locus was found by genome-wide association studies. In present study, height prediction model was established by WAS and obtained an AUC of 0.67 (95％CI:0.53-0.90). Conclusion It has reference value for predicting the height of Han male in Shandong province by WAS model based on 547 SNPs loci, while it is still necessary to further promote the accuracy of the prediction model by screening more height-associated SNPs loci with population heterogeneity.
