Research Progress of CircRNA and Its Application Prospect in Forensic Medicine
10.3969/j.issn.1004-5619.2018.01.014
- VernacularTitle:circRNA研究进展及其法医学应用展望
- Author:
Chun-Yan TU
1
;
Kai-Di JIN
;
Cheng-Chen SHAO
;
Bao-Nian LIU
;
Ya-Qi ZHANG
;
Jian-Hui XIE
;
Yi-Wen SHEN
Author Information
1. 复旦大学基础医学院法医系
- Keywords:
forensic genetics;
circRNA;
review;
genetic markers;
biological markers
- From:
Journal of Forensic Medicine
2018;34(1):73-78
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA(circRNA)is a type of noncoding RNA with tissue specificity and high stabil-ity, which forms a closed continuous loop and is abundantly expressed in tissue cells. According to re-cent research, the regulatory function of circRNA elucidating in the occurrence and development of dis-ease shows a potential for diagnosing clinical disease and revealing disease mechanism. This paper re-views the biological characteristics, analysis methods of circRNA and its research progress in clinical ap-plication as biomarker, and outlooks its application in the field of forensic medicine.
