Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate
10.11895/j.issn.0253-3820.171347
- VernacularTitle:二硫化钼量子点荧光传感器检测盐酸多西环素的研究
- Author:
Xiang-Yu JIANG
1
;
Hua FU
;
Min ZHANG
;
Zhi-Bo FU
;
Yue-Rong WANG
;
Hong-Yang ZHANG
;
Ping HU
Author Information
1. 上海市功能性材料化学重点实验室
- Keywords:
Molybdenum disulfide;
Quantum dot;
Fluorescence sensor;
Doxycycline hyclate
- From:
Chinese Journal of Analytical Chemistry
2018;46(7):1077-1083
- CountryChina
- Language:Chinese
-
Abstract:
Molybdenum disulfide ( MoS2) quantum dots ( QDs) were synthesized using one-step hydrothermal method with an acceptable fluorescence property. Based on the quenching effect between doxycycline hyclate ( DOX) and MoS2QDs, a fluorescence method for detection of DOX was established. The interaction between MoS2QDs and DOX was discussed with a final proposal of the static quenching mechanism. A good linear correlation for detection of DOX using fluorescenct MoS2QDs was obtained in the concentration range of 0. 86-55. 40 μg/mL, with a detection limit of 0. 023 μg/mL (S/N=3). The fabricated sensor was applied to the detection of DOX in real samples with RSDs of less than 5% . The relative error of determination results of MoS2QDs method compared with HPLC was from -4. 5% to 0. 8% and -4. 6% to 2. 8% for DOX tablet and DOX spiked milk, respectively. The fluorescence detection of DOX in real sample using MoS2QDs was simple, rapid and reliable.
