Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor
10.11895/j.issn.0253-3820.171444
- VernacularTitle:功能核酸生物传感器检测金属离子的研究进展
- Author:
Zai-Hui DU
1
;
Xiang-Yang LI
;
Jing-Jing TIAN
;
Yang-Zi ZHANG
;
Hong-Tao TIAN
;
Wen-Tao XU
Author Information
1. 河北农业大学
- Keywords:
Functional nucleic acid;
Metal ions;
Mode of action;
Biosensor;
Review
- From:
Chinese Journal of Analytical Chemistry
2018;46(7):995-1004
- CountryChina
- Language:Chinese
-
Abstract:
Functional nucleic acids are natural or artificialnucleic acid sequences with specific functions and special structures. Special metal ions are essential trace elements for human health, but excessive metal ions will be harmful to human health. The functional nucleic acids are widely used in the detection of metal ions because of their advantages such as easy modification, low price, high stability and strong specificity. This review describes the function of functional nucleic acid and metal ions, mainly including cutting type, link type, metal ion-mediated base pairing, click chemical type, conformation change type, and other types. Then, biosensor of functional nucleic acid combined with different signal output is introduced. Finally, the research significance and problems of functional nucleic acid in metal ion detection are discussed, and the future development direction and application prospect of functional nucleic acid biosensor are prospected.
