Application of Single Solid State Nanopore / Nanochannel Based on Polymer Membrane and Glass Nanopipette in Analytical Chemistry
10.11895/j.issn.0253-3820.181256
- VernacularTitle:基于高分子聚合物及毛细玻璃管的固态单纳米孔通道 在分析化学中的应用
- Author:
Qing-Feng ZHAI
1
;
Jing LI
;
Er-Kang WANG
Author Information
1. 中国科学院长春应用化学研究所
- Keywords:
Single solid nanopore / nanochannel;
Resistive pulse;
Ion current rectification;
Sensor;
Responsive gate;
Review
- From:
Chinese Journal of Analytical Chemistry
2018;46(6):814-825
- CountryChina
- Language:Chinese
-
Abstract:
Nanopore / nanochannel sensing technique drawing more attention in analytical chemistry due to its unique advantages and the fabricated electrochemical sensors and electrochemical responsive gates have been widely used for more target detection, including single molecule protein and DNA sequencing. Nanopore /nanochannel that used for fabricating electrochemical detection system is mainly divided into biological nanopore and solid state nanopore, and among them, solid state nanopore / nanochannel has a wide range of application due to its inherent properties, such as easy for modification, good mechanical property and stability. Resistive pulse sensing and current-voltage curves (ion current rectification) are two main methods of nanopore / nanochannel sensing technique used for target analysis, so in this review, we introduced the fundamentals and applications of nanopore sensing technique based on the above two methods. In addition, we concluded the application and development of single state nanopore / nanochannel in recent years, and also gave a brief look at the future challenges and prospects in the development of this field.
