Progresses of Single Molecular Fluorescence Resonance Energy Transfer in Studying Biomacromolecule Dynamic Process
10.11895/j.issn.0253-3820.181136
- VernacularTitle:单分子荧光共振能量转移 用于生物大分子构象动态变化过程研究进展
- Author:
Le-Le SUN
1
;
Ying-Ying SU
;
Yan-Jing GAO
;
Wei LI
;
Hui LYU
;
Bin LI
;
Di LI
Author Information
1. 中国科学院上海应用物理研究所
- Keywords:
Single molecular fluorescence resonance energy transfer;
Biomacromolecule;
Structural dynamic;
Interaction;
Review
- From:
Chinese Journal of Analytical Chemistry
2018;46(6):803-813
- CountryChina
- Language:Chinese
-
Abstract:
Biomacromolecules participate in various kinds of vital processes. Observing and analyzing their structural dynamic and the dynamic processes of intermolecular interaction at molecular level is important for understanding the action mechanism. Since its advent, single molecular fluorescence resonance energy transfer (SM-FRET) has demonstrated its great potential in studying the conformational change and interaction process of biomacromolecules, and a series of new mechanisms have been revealed. This review summarized recent progresses of SM-FRET in studying protein structural dynamic, nucleic acid structural dynamic, protein-protein and protein-nucleic acid interactions.
