Electrochemical Detection of Dopamine Based on MnO2 Nanowires/Reduced Graphene Oxide Composites Modified Glassy Carbon Electrode
10.11895/j.issn.0253-3820.171183
- VernacularTitle:基于MnO2纳米线-还原石墨烯复合修饰电极的多巴胺电化学检测
- Author:
Quan-Guo HE
1
;
Jing LIANG
;
Guang-Li LI
;
Pei-Hong DENG
;
Jun LIU
;
Xiao-Peng LIU
Author Information
1. 湖南工业大学生命科学与化学学院
- Keywords:
MnO2nanowires;
Reduced graphene oxide;
Modified electrode;
Dopamine;
Electrocatalytic oxidation
- From:
Chinese Journal of Analytical Chemistry
2018;46(3):438-445
- CountryChina
- Language:Chinese
-
Abstract:
MnO2nanowires-reduced graphene oxide composite (MnO2-RGO) was used to modify glassy carbon electrodes (GCE) and applied for the electrochemical determination of dopamine (DA). The microstructure of MnO2nanowires and MnO2-RGO nanocomposite material was characterized by scanning microscope and X-ray powder diffraction. Then the electrochemical reduction condition for preparing MnO2-RGO/GCE and experimental conditions for determining DA were optimized systematically. The electrochemical behavior of DA on the bare electrode and RGO or MnO2-RGO modified electrodes was also investigated in pH 3.5 phosphate buffer solution (PBS) by cyclic voltammetry. The results shows that the oxidation peaks of ascorbic acid (AA), dopamine (DA) and uric acid (UA) can be well separated and the peak to peak separations were 268 mV (AA-DA) and 128 mV (DA-UA), respectively. Moreover, the linear response ranges for the determination of DA were 0.06-1.0 μmol/L and 1.0-80 μmol/L with the detection limit of 1.0 nmol/L (S/N=3). The proposed method has been applied to the determination of dopamine in human blood serum sample with satisfactory results.
