Progress in Molecular Chaperone Regulation of Heat Shock Protein 90 and Cancer
10.11895/j.issn.0253-3820.171024
- VernacularTitle:热休克蛋白90的分子伴侣调控与癌症研究进展
- Author:
Rui ZHAI
1
;
Xiao-Yun GONG
;
Xing-Chuang XIONG
;
You JIANG
;
Ze-Jian HUANG
;
Xiang FANG
Author Information
1. 中国计量科学研究院,北京100013
- Keywords:
Heat shock protein 90;
Molecular chaperone;
Cancer;
Review
- From:
Chinese Journal of Analytical Chemistry
2018;46(3):301-310
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 90 (HSP90) is a member of genetically conserved heat shock protein family. As an important molecular chaperone in eukaryotic cells, HSP90 plays a key regulatory role in maintaining cellular protein homeostasis. HSP90 clients encompass a wide range of proteins, thus HSP90 is involved in diverse biological process. With the deeper study, it is found that HSP90 takes an important part in the development and metastasis of cancer,and has become a promising target for the study of anticancer biology. We review the progress of HSP90 as molecular chaperone and its relationship with cancer.
