Determination of Paraben and Its Metabolite in Sediments by Ultra Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry
10.11895/j.issn.0253-3820.170330
- VernacularTitle:超高效液相色谱-三重四极杆质谱测定沉积物中6种对羟基苯甲酸酯及其代谢产物
- Author:
Jia-Hui ZHAO
1
;
Jing-Lan FENG
;
Nan-Nan XI
;
Jian-Hui SUN
Author Information
1. 河南师范大学化学与环境科学学院
- Keywords:
Ultra performance liquid chromatography-triple quadrupole tandem mass spectrometry;
Benzoic acid esters;
Sediment
- From:
Chinese Journal of Analytical Chemistry
2018;46(2):260-264
- CountryChina
- Language:Chinese
-
Abstract:
A new method for simultaneous determination of six benzoic acid esters and their metabolite p-hydroxybenzoic acid (p-HB) in sediments was developed.The samples were extracted with methanol and water,and then the extraction was purified by Oasis MCX solid phase column.The separation of targets was conducted by passing through a UPLC?HSS T3 column with a methanol-0.1% acid aqueous solution as the mobile phase under gradient elution.The qualitative analysis of the analytes was measured by Ultra performance liquid chromatography-Triple quadrupole tandem mass under multiple reaction monitoring mode (MRM) and the internal standard method was applied for quantitative analysis.The results indicated that seven target substances had a good linear relationship in the range of 0.1-500 μg/L with correlation coefficients above 0.9995 and the detection limits of 0.75-1.23 ng/g.The recoveries ranged from 65.5% to 88.3% and the relative standard deviation was 7.4%-13.6%.This method was suitable for the measurement of benzoic acid esters with the advantages such as simple processing,good selectivity and high sensitivity.
