Study on Inclusion Behavior of Carbendazim with Cyclodextrins
10.11895/j.issn.0253-3820.170031
- VernacularTitle:多菌灵与3种环糊精的识别研究
- Author:
Wei SUN
1
;
Meng-Yao SHE
;
Si-Yue MA
;
Jiao CHEN
;
Zhen SHI
;
Jian-Li LI
Author Information
1. 西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室
- Keywords:
Carbendazim;
Cyclodextrins;
Nuclear magnetic resonance;
Inclusion
- From:
Chinese Journal of Analytical Chemistry
2018;46(2):246-253,后插5-后插10
- CountryChina
- Language:Chinese
-
Abstract:
Hydrophobic medicine carbendazim,come into inclusion compounds with β-cyclodextrin(β-CD),2-hydroxypropyl-β-CD (2-Hp-β-CD) and 2,6-dimethyl-β-CD(Me-β-CD),were made by solvent method.By investigating the inclusion behaviors of these three cyclodextrins combined with carbendazim using 1H NMR,2D rotating frame overhause effect spectroscopy (ROESY) and diffusion ordered spectroscopy,the possible ways of combinations and the recognition ratio of this three inclusion compounds,Dβ-CD=2.516×10-10m2/s,D2-Hp-β-CD=1.676×10-10m2/s,DMe-β-CD=2.046×10-10m2/s,were obtained.According to X-ray power diffraction,thermogravimetric analysis,infrared spectroscopy and scanning electron spectroscopy characterization,it was found that the characteristic diffraction peaks changed after carbendazim and cyclodextrin formed into inclusion compounds,and the characteristic diffraction peak of carbendazim at 10.4°,21.2°,25.8°,31.5°(2θ) lost or disappear.The pyrolysis temperature of carbendazim was 197.5℃,and would be higher than 260℃ after it formed inclusion complex.The infrared spectrum also showed that the oscillation peaks of inner cyclodextrin cavum apparently reduced after carbendazim combined,which demonstrated that the position of water molecules inside cyclodextrin cavum were occupied by the carbendazim molecules.With the help of SEM,the appearances of inclusion were different from a single carbendazim molecule,which manifested a new structure appeared.
