Prognostic factors analysis of nasal NK/T cell lymphoma

VernacularTitle:112例鼻腔NK/T细胞淋巴瘤的预后分析
Author: Qi CHEN ¹ ; You WANG ; Yunpeng BA ; Yuan ZHANG
Author Information

1. 郑州大学第一附属医院鼻科
Keywords: Lymphoma,Extranodal NK-T-Cell; Nasal Cavity; Prognosis; Ki-67 Antigen
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2017;24(11):593-596
CountryChina
Language:Chinese
Abstract: OBJECTIVE To investigate the prognosis of nasal NK/T cell lymphoma.METHODS The clinical data of 112 patients with a primary diagnosis of nasal NK/T cell lymphoma treated at the First Hospital of Zhengzhou University between January 2010 and June 2017 were studied.The association between clinical parameters and survival rate was evaluated by Kaplan-Meier method and Cox regression model.RESULTS The 1-,3-,5-year overall survival were 92％,72％ and 54％ respectively.Single factor analysis displayed that age,gender,the level of albumin,the expression level of Ki-67,treatment model,complete response rate to the primary treatment and the interval between symptom onset to diagnosis were related to the prognosis factors.Multivariate analysis showed that the interval of first time of symptom onset to the time of diagnosis and the positive rate of Ki-67 more than 50％ were the independent risk factors for the prognosis of nasal NK/T lymphoma.CONCLUSION The interval of symptom onset to the time of diagnosis and the positive rate of Ki-67 may be independent prognostic factors for NK/T cell lymphoma.