Expression and its clinical significance of zonula occluden-1 in hypopharyngeal squamous cell carcinoma
10.16066/j.1672-7002.2017.11.004
- VernacularTitle:紧密连接蛋白-1在下咽鳞状细胞癌组织中的表达及临床意义
- Author:
Shufang ZHOU
1
;
Xu WANG
;
Hao WU
;
Peng DA
;
Huaci MA
;
Qingwen CHEN
;
Shu ZHANG
Author Information
1. 南通大学附属海安医院耳鼻咽喉科
- Keywords:
Hypopharyngeal Neoplasms;
Immunohistochemistry;
Prognosis;
ZO-1
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(11):565-568
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of zonula occluden-1(ZO-1) in hypopharyngeal squamous cell carcinoma(HSCC) and its clinical significance.METHODS Immunohistochemistry with tissue microarrays was used to detect the expression of the ZO-1 protein in 52 cases of HSCC.The correlation of prognosis and clinicopathological features was analyzed.RESULTS The expression of ZO-1 protein in HSCC was lower than that in adjacent tissues,its expression was closely related with tumor differentiation,tumor stage,tumor location and lymphatic metastasis.The Log-rank univariate analysis showed that the prognosis of HSCC was related to tumor differentiation,tumor stage,lymphatic metastasis and tumor location.The patients with lower expression of ZO-1 showed the worse prognosis than patients with higher expression of ZO-1.As shown in the Cox regression analyses,tumor differentiation,lymphatic metastasis,the ZO-1 expression and tumor stage were all independent prognostic factors.CONCLUSION The ZO-1 can serve as an independent prognostic factor of HSCC,and the low expression of ZO-1 is closely related to poor prognosis.
