Clinical analysis of patients with Laryngopharyngeal reflux disease
10.16066/j.1672-7002.2017.10.012
- VernacularTitle:咽喉反流性疾病临床分析
- Author:
Lei CHENG
1
;
Fengxin SUN
;
Ruo JIA
;
Feng LI
Author Information
1. 北京市大兴区人民医院耳鼻咽喉头颈外科
- Keywords:
Signs and Symptoms;
laryngopharyngeal reflux disease;
proton pump inhibitor
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(10):540-542
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the changes of symptoms and signs of laryngopharyngeal reflux diseases(LPRD) after treatment with esomeprazole.METHODS The suspected LPRD patients were treated with esomeprazole for 8 weeks.Reflux finding score(RFS) and reflux symptoms index(RSI) score were evaluated before and after treatment.RESULTS In RSI,84% of the patients had the symptom of hoarseness or a problem with voice,87% had clearing of throat,71%had excess throat mucus,58% had difficulty swallowing food,52% had coughing after eat or after lying down,68% had breathing difficulties or chocking episodes,79% had troublesome or annoying cough,92% had lump in your throat or sensation of something sticking in throat,and 32% had heartburn,chest pain,indigestion or stomach acid coming up.In the RFS,45% of the patients had pseudosulcus,57% had ventricular obliteration,94% had erythema/hyperemia,85% had vocal cord edema,82% had diffuse laryngeal edema,83% had posterior commissure hypertrophy,10% had granuloma/granulation,and 58% had thick endolaryngeal mucus.The RSI and RFS score had statistical difference before and after treatment(P<0.001).CONCLUSION The main symptoms of LPRD were lump in throat or sensation of something sticking in throat,clearing of throat and hoarseness or a problem with voice.The main signs of LPRD were erythema/hyperemia,vocal cord edema and posterior commissure hypertrophy.The PPI has marked improved in symptoms and signs of LPRD.