Comparison of the effects of post-aural injection of methylprednisolone and dexamethasone in flat-type sudden hearing loss
10.16066/j.1672-7002.2017.01.006
- VernacularTitle:耳后注射甲泼尼龙琥珀酸钠与地塞米松治疗平坦型突发性聋的对比研究
- Author:
Xiaoming WANG
1
;
Lihui WEN
;
Zhong LYU
Author Information
1. 钦州市第二人民医院耳鼻咽喉头颈外科
- Keywords:
Hearing Loss,Sudden;
Glucocorticoids;
Clinical Protocols;
post-aural injection
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare the effects of post-aural injection of methylprednisolone and dexamethasone in flat-type sudden hearing loss.METHODS 142 patients with flat-type sudden hearing lossin our hospital were selected and divided into methylprednisolone group and dexamethasone group randomly.All patients in these two groups received local injection of glucocorticoidsoncein mastoid periosteum.Patients in methylprednisolone group were injected methylprednisolone solution;Patients in dexamethasone group were injected dexamethasone solution.The efficacy,hearing improvement of two groups were compared.RESULTS After the treatment,the recovery rate of methylprednisolone and dexamethasone group were 25.35％ and 16.90％,the total effective rate was 88.73％ and 63.38％,respectively;Each clinical index between two groups had statistically significant difference (P＜0.05);Moreover,the hearing improvement in methylprednisolone group was much better than dexamethasone group,withan averagedincrease of (26.5 ±4.3) dB in 125-250 Hz in methylprednisolone group while only (18.5 ± 6.2) dB in 125-250 Hz in dexamethasone group,which demonstrated statistical significantly difference(P＜0.05).CONCLUSION The clinical efficacy of local injection with methylprednisolone was better than dexamethasone,and demostrated mild adverse reactions,which could be widely applied in clinical therapy.
