Clinical significance of serum microRNA-222-3p expression in papillary thyroid carcinoma
10.16066/j.1672-7002.2017.01.003
- VernacularTitle:血清微小RNA-222-3p在甲状腺乳头状癌中的表达及意义
- Author:
Jinwang DING
1
;
Keyi WANG
;
Dingcun LUO
;
Qiaofeng TU
;
Yu ZHANG
;
Jingjing SHI
;
You PENG
;
Wo ZHANG
;
Gang PAN
;
Liuqing YE
Author Information
1. 南京医科大学附属杭州医院(杭州市第一人民医院)肿瘤外科
- Keywords:
Thyroid Neoplasms;
MicroRNAs;
Diagnosis;
microRNA-222-3p;
aggressiveness
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2017;24(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression of serum miR-222-3p in papillary thyroid carcinoma and its clinical significance.METHODS Total RNA in serum was extracted from 121 patients of papillary thyroid carcinoma and benign thyroid diseases.The reverse transcription quantitative real-time polymerase chain reaction(qRT-PCR) method was used to detect the expression of miR-222-3p,and then the potential correlation between serum miR-222-3p and clinical pathological characteristics of papillary thyroid carcinoma was analyzed.The receiver operating characteristic area under the curve(ROCAUC) and their index for diagnosis evaluation were also calculated.RESULTS The median expression level of serum miR-222-3p in papillary thyroid carcinoma patients was significantly higher than that of control group (2.2188 vs 0.7022,P=0.002).Although the expressions of serum miR-222-3p was not associated with the gender,age,capsule invasion,TNM stage,but it was positively correlated with tumor size,bilateral involvement,lesion quantity and lymph node status.ROC curve analysis showed that the specificity and sensitivity of the miR-222-3p diagnosis of papillary thyroid cancer were 79.75％ and 61.90％,respectively,while the ROC-AUC was 0.717.CONCLUSION The serum miR-222-3p is over expressed in papillary thyroid carcinoma and its expression is significantly correlated with tumor progression.It will be helpful for PTC diagnosis.
