Effects of TPF-DM on Nutrient Indexes and Immune Function in Severe Traumatic Brain Injury Patients
10.16151/j.1007-810x.2018.02.004
- VernacularTitle:糖尿病专用型肠内营养混悬液对重型脑损伤病人营养指标以及免疫功能的影响
- Author:
Kai-Xuan YAN
1
;
Cheng CAO
;
Lei YANG
;
Hu-Xu WANG
;
Wei WU
;
Heng GAO
Author Information
1. 东南大学医学院附属江阴医院
- Keywords:
Enteral nutrition;
Immune function;
Blood glucose;
Severe traumatic brain injury
- From:Parenteral & Enteral Nutrition
2018;25(2):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of TPF-DM on blood glucose levels and immune function in severe traumatic brain injury (STBI) patients.Methods:We consecutively included 60 STBI patients who were randomly divided into control and experimental groups.The two groups of patients were treated with TPF and TPF-DM as the main energy supply,respectively.Total protein,albumin,prealbumin,procalcitonin (PCT),immunoglobulinM (IgM),immunoglobulinG (IgG),immunoglobulinA (IgA) and blood glucose of all patients were detected on day 1,7 and 14.Immune function related indicators,serum protein and blood glucose were statistically analyzed.Results In the first week,the mean blood glucose level and incidence of hypoglycemia were not significantly different between the two groups (P ＞ 0.05).However,the blood glucose variability (BGV) was significantly different (P ＜ 0.05).In the second week,both the blood glucose level and BGV were in normal range with no significant difference between two groups (P ＞ 0.05).At dayl,the total protein,albumin,prealbumin,IgM,IgG and IgA of all the patients were below the normal level,while the PCT was exact opposite,but with no significant difference between the two groups (P ＞ 0.05).At day7,PCT decreased compared to dayl in both the control and experimental groups,while the total protein,albumin,prealbumin,IgM,IgG and IgA increased,but the experimental group increased much more compare to the control group (P ＜ 0.05).At dayl4,all these indexes returned to normal levels with no significant difference between the two groups (P ＞ 0.05).Conclusion:TPF-DM is significantly better than TPF to control the blood glucose level.TPF-DM may have a positive effect on the control of early excessive inflammation and infection,and then improve the immune function.Yet the potential physiopathologic mechanism needs further study.
