Comparison of the therapeutic effect of preoperative and postoperative chemoradiotherapy for locally advanced rectal cancer
10.3969/j.issn.1671-8348.2018.16.015
- VernacularTitle:局部晚期直肠癌术前与术后放化疗对比研究
- Author:
Chan CHENG
1
;
Shan JIN
;
Wen PENG
;
Ying JIANG
;
Xueying SI
;
Wen LUO
;
Tingting NI
;
Shisheng TAN
Author Information
1. 贵州医科大学
- Keywords:
locally advanced rectal neoplasms;
preoperative chemoradiotherapy;
postoperative chemoradiotherapy;
bevacizumab
- From:
Chongqing Medicine
2018;47(16):2173-2176,2180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effect of preoperative chemoradiotherapy or postoperative adjutant chemoradiotherapy for locally advanced rectal cancer.Methods The clinical data of 76 patients with locally advanced rectal cancer from 2011 to 2016 in Guizhou Provincial People's Hospital were retrospectively analysed.A total of 30 cases received preoperative chemoradiotherapy (group A),5 of them received concurrent chemoradiotherapy combined with bevacizumab target treatment.The other 46 cases (group B) were given post-operative adjutant chemoradiotherapy.Both group A and group B were treated with intensity-modulated radiation therapy (IMRT).The chemoradiotherapy regime was as follows:the median of target volume dose was 50.4 Gy (45.0-55.8 Gy);the median of chemotherapy sessions was 26 times (24-28 times).Capecitabine tablets (825 mg/m2,twice a day) were also given on the date of chemotherapy.The clinical data and follow-up results of all patients were compared between the two groups.Results The five-year disease free survival rates of group A and group B were 66.7％ and 57.7％,respectively;and the five-year overall survival rates of group A and group B were 81.8％ and 73.0％,respectively,no statistically significant difference was found between the two groups (P=0.599,0.489).The anus-preserving rates of patients with tumor below peritoneal reflection in group A and group B were 56.52％ and 25.00％,there was statistically significant difference (P=0.045).In the group A,86.6 ％ patients resulted in down-staging,including 3 cases with complete pathologic response.Conclusion Preoperative chemotherapy could down tumor stage and improve rates of anal preservation and local control without increasing possibility of postoperative complications.Preoperative chemotherapy in combination with bevacizumab target treatment may be more effective in lowering tumor stage.
