Study on effect of exercise training combined with drugs on cardiac autonomic neuropathy in type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2018.15.009
- VernacularTitle:运动训练联合药物治疗对2型糖尿病心脏自主神经病变的影响研究
- Author:
Xueyan WENG
1
;
Mianxiong CHEN
;
Hui LIN
Author Information
1. 海南省海口市人民医院内分泌科 570208
- Keywords:
diabetes,type 2;
cardiovascular autonomic neuropathy;
heart rate recover;
exercise training
- From:
Chongqing Medicine
2018;47(15):2007-2010
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of exercise on the cardiovascular autonomic neuropathy (CAN) in type 2 diabetes mellitus(T2DM) and related risk factors of heart rate recover (HRR).Methods One hundred and five patients with definitely diagnosed T2DM were selected as the research subjects.All patients underwent the oral glucose tolerance test and treadmill exercise test before and after treatment.The related risk factors leading to abnormal HRR were analyzed.Abnormal HRR was divided into the general therapy group (GT) and the intensive therapy group (IT) according to different treatment schemes.The GT group used metformin and diet control,whereas on this basis the IT group accepted the mild enhancement exercise training.The clinical biochemical indicators and HRR change before and after treatment were compared between the two groups.Results Abnormal HRR had significant correlation with FBG,HbA1c,resting heart rate,maximal heart rate and systolic blood pressure(SBP)(P＜0.05).After two-month mild enhancement exercise training,FBG,HbA1c and resting heart rate in the GT group and IT group were significantly decreased compared with those before treatment(P＜0.05),while HRR was significantly increased;compared with those after treatment in the GT group,the FBG,HbA1c levels and resting heart rate in the IT group were significantly decreased,while HRR was significantly increased (P＜0.05).Conclusion FBG,HbA1c and resting heart rate are the important risk factors for abnormal HRR in T2DM patients,mild enhancement exercise training could reduce blood glucose level and increases HRR,thus effectively improve cardiac autonomic neuropathy.
