Meta-analysis on effect and safety of Yupingfeng Powder combined with antihistamines for chronic urticaria

VernacularTitle:玉屏风散联合抗组胺药治疗慢性荨麻疹有效性和安全性的Meta分析
Author: Cuicui SHEN ¹ ; Meng LV ; Chuanjian LU
Author Information

1. 广州中医药大学第二临床医学院
Keywords: chronic urticaria; yupingfeng powder; systematic review; meta-analysis; randomized controlled trials
From: Chongqing Medicine 2018;47(13):1758-1762
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect and safetyof Yupingfeng Powdercombined with antihistamines for the treatment of patients with chronic urticaria.Methods Searched all randomized controlled trials (RCTs)of Yupingfeng Powder for treatment of chronic urticaria from the databases of CENTRAL,Pubmed,Embase,CNKI,CBM,VIP and Wanfang.Two researchers independently searched the literature and used the Cochrane system evaluation method to evaluate the quality of the study,and used RevMan 5.3 for meta-analysis.Results A total of 10 RCTs involving 964 patients were included in this study.Meta-analysis showed that compared with antihistamines alone,Yupingfeng Powder combined with antihistamines could improve the clinical effective rate (OR=2.83,95 ％ CI:1.89-4.25,P ＜ 0.01),reduce relapse rate (OR =0.13,95 ％ CI:0.07-0.24,P＜0.01) and reduce the incidence of adverse reactions (OR=0.40,95％CI:0.19-0.83,P=0.01).Conclusion Yupingfeng Powder combined with antihistamines has superior clinical effective rate,lower recurrence rate and incidence of adverse reactions.