The effect of stereotactic radiosurgery treatment for recurrent high grade glioma with MRI and MRS
10.3969/j.issn.1671-8348.2018.13.016
- VernacularTitle:MRI联合MRS辅助立体定向放射治疗复发高级别胶质瘤的疗效观察
- Author:
Hong LIANG
1
;
Mingliang REN
;
Yibo YAO
;
Minhui XU
;
Lunshan XU
Author Information
1. 陆军军医大学大坪医院神经外科
- Keywords:
magnetic resonance spectroscopy;
radiosurgery;
recurrent high grade glioma
- From:
Chongqing Medicine
2018;47(13):1756-1757,1762
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of MRS-assisted stereotactic radiosurgery (SRS) for small recurrent high grade glioma (HGG).Methods A total of 54 patients with recurrent HGG were selected,the tumor diameter was less than 3 cm,the patients were divided into the conventional MRI group of 26 cases,and MRI+MRS group of 28 cases.The target region of the conventional MRI group was defined as the enhanced and short T1,long T2 area;MRI+MRS group was defined as the region of Cho/NAAindex (CNI) ≥1.6 in the surrounding short T1,long T2 and enhanced area.All the patients were followed up at least 12 months,analysed their therapeutic effect.Results Compared with the conventional MRI group,MRS+MRI group margin dose increased (19.46 Gy vs.13.58 Gy),the average diameter of target were smaller (2.6 cm vs.3.0 cm),progression-free survival was longer (6.8 months vs.5.6 months),the 1-year survival rate was higher (78.6％ vs.50.0％),and the occurrence rate of brain edema was lower (5 vs.17),the difference was statistically significant (P＜0.05).Conclusion MRI+-MRS assisted SRS helps to accurately identify the scope of HGG,its short term effect was superior.
