Cognitive function of remitted schizophrenia patients and their first-degree non-psychotic relatives
10.3969/j.issn.1671-8348.2018.13.011
- VernacularTitle:缓解期的精神分裂症患者及其一级非患病亲属的认知功能比较分析
- Author:
Yingying FENG
1
;
Xiaohua HU
;
Yan TIAN
;
Yun JIANG
;
Zongqing WANG
;
Zuohui GAO
;
Ling BAO
Author Information
1. 华中科技大学同济医学院附属武汉精神卫生中心
- Keywords:
schizophrenia;
cognition;
first-degree non-psychotic relative;
remission;
endophenotype
- From:
Chongqing Medicine
2018;47(13):1740-1742,1745
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore difference of neuropsychological tests between the remitted schizophrenia patients and the first-degree non-psychotic relatives of schizophrenia patients,and to explore the possible endophenotypes in cognitive function.Methods The MATRICSTM consensus cognitive battery was administered to 86 remittent schizophrenia patients (the patient group),86 first-degree non-psychotic relatives of schizophrenia patients (the relative group),and 86 healthy people (the control group).Results Compared with the control group,the patients group and the relative group showed poor performance on trail making test,brief assessment of cognition,hopkins verbal learning,mazes,category fluency,emotional intelligence test and continuous performance test (P＜0.05).There were significantly lower performances in the patient group than the relative groups on hopkins verbal learning,mazes,emotional intelligence test and continuous performance test (P＜0.05).Conclusion The remitted schizophrenia patients and their first-degree non-psychotic relatives have selective deficits in cognition function,among them,verbal leaning,attention/vigilance,reasoning and problem solving and social cognition may be potential endophenotypes for schizophrenia.
