Expression and significance of CXCL12, CXCR4, MVD in MM bone marrow micro niche
10.3969/j.issn.1671-8348.2018.13.009
- VernacularTitle:CXCL12、CXCR4、MVD在多发性骨髓瘤骨髓微龛中表达及意义
- Author:
Jun ZHOU
1
;
Li YE
;
Fanli LIN
;
Shuyue WANG
;
Xiaoming LI
;
Chunlan HUANG
Author Information
1. 西南医科大学临床医学院
- Keywords:
multiple myeloma;
CXCL12;
CXCR4;
microvessel density
- From:
Chongqing Medicine
2018;47(13):1733-1736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study expression,distribution,significance and relationship of CXCL12,CXCR4,microvessel density (MVD) in multiple myeloma (MM) bone marrow micro niche.Methods 63 cases of patients with MM were chosen as the experimental group,42 cases of healthy persons were chosen as the control group.The expression and distribution of CXCL12,CXCR4,MVD were detected by immunohistochemical method.Results Compared with the control group,the expressions of CXCL12,CXCR4,MVD in the experimental group were higher,the difference was statistically significant (P ＜ 0.05),their expressions in bone marrow were not significantly different from gender,age,immunoglobulin type and light chain classification (P＞0.05);the expression of CXCR4,MVD were positively related with CXCL12 (P＜0.05).Conclusion The expression of CXCL12,CXCR4,MVD may be related to the occurrence of MM;CXCL12/CXCR4 biological axis could promote the angiogenesis of MM bone marrow micro niche.
