Preliminary study on the role of protein HPC2 in the regulation of HPV16 infected cervical cancer cells
10.3969/j.issn.1671-8348.2018.13.005
- VernacularTitle:HPC2蛋白在HPV16感染的宫颈癌细胞中调控作用初探
- Author:
Ling LIU
1
;
Haihong DU
;
Lingye FAN
;
Dan NIE
;
Xiguang MAO
Author Information
1. 西南医科大学附属医院妇产科
- Keywords:
cervical neoplasm;
siha cell;
E7;
HPC2
- From:
Chongqing Medicine
2018;47(13):1720-1722,1726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of human homologue of polycomb 2 (HPC2) on the growth of cervical cancer cells siha and the regulation of E7 gene.Methods HPC2 and E7 genes of siha cells were silenced by siRNAs respectively.Detected the expression of HPC2 gene and protein in siha cell lines after E7 gene silencing,cell proliferation activity and the rate of cell apoptosis.Results The expressions of HPC2 mRNA and protein were decreased in siha cells with E7 gene silencing,cell proliferation was inhibited,and apoptosis was increased,which was similar to HPC2 gene silencing.Conclusion HPC2 may be involved in the regulation of cell proliferation and apoptosis,and its expression may be closely related to E7 gene in SiHa cells.
