Study on the effect of γδT cell activated in mice islet transplantation rejection
10.3969/j.issn.1671-8348.2018.13.001
- VernacularTitle:探讨γδT细胞在小鼠胰岛移植排斥反应中的作用
- Author:
Chuangui LI
1
;
Yajun SON
;
Jiacai YANG
;
Chibing HUANG
Author Information
1. 解放军第八十八医院泌尿外科
- Keywords:
γδT cell;
blood glucose;
islet transplantation;
transplant rejection
- From:
Chongqing Medicine
2018;47(13):1705-1708
- CountryChina
- Language:Chinese
-
Abstract:
Objective After the islet transplantation,observed blood glucose and survival time in the islet transplantation mice model to explore the effect of intestinal epithelial γδT cell in islet transplantation rejection.Methods Established the mice model of islet transplantation,divided into wild type mice group,γδ gene knockout mice group and γδ gene knockout γδT cell reinfusion mice group,observed blood glucose in 1,3,5,7,9,11,13,15,17,19,21,23,25,27,29 days after surgery and pathological conditions aft er two weeks of transplantation.Results After transplantation,the rising blood glucose of wild type mice group and γδ gene knockout γδT cell reinfusion mice group were significantly slower than that of γδ gene knockout mice group (P＜0.05),but there was no significant difference in between two groups (P＞0.05).The survival time of wild-type mice group was (27±2) days,and γδ gene knockout γδT cell reinfusion mice group was (24±1) days,they were significantly longer than (17±3) days of γδ gene knockout mice group (P＜ 0.05).Conclusion As a special kind of T cells,γδT intestinal epithelial cell plays an important role in the islet transplantation rejection.
