Correlation between gene C242T polymorphism and large artery atherosclerotic cerebral infarction in the population of Han nationality of Shanghai's Songjiang district
10.3969/j.issn.1671-8348.2018.12.014
- VernacularTitle:C242T基因多态性与大动脉粥样硬化型脑梗死的相关性研究
- Author:
Fangping YU
1
;
Ping JIANG
;
Yingchun ZHAO
;
Limin LI
;
Yongyi YANG
Author Information
1. 上海交通大学附属第一人民医院松江分院老年干部科
- Keywords:
NADPH oxidase;
C242T polymorphism;
atherosclerosis;
cerebral infarction
- From:
Chongqing Medicine
2018;47(12):1620-1624
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22phox subunit C242T gene polymorphism and large artery atherosclerotic cerebral infaretion(LAACI) among Han population in Songjiang district of Shanghai city.Methods The polymerase chain reaction-restrictive fragment length polymorphism analysis and gene sequencing techniques were adopted to conduct the gene type and allele frequency detection of C242T gene polymorphism loci in 310 Han patients with LAACI and 330 healthy individuals as control group in Shanghai Songjiang area.Then the correlation between C242T gene polymorphism and LAACI was analyzed.Results The level of MDA and the activity of NADPH oxidase in the LAACI group were significantly higher than those in the control group (P＜0.05).The smoking rate,alcohol drinking rate,hypertension rate,systolic pressure,diastolic pressure,and levels of blood glucose,TC,TG,LDL,ox-HDL and ox-LDL in the LAACI group were higher than those in the control group (P＜0.05),while the HDL level in LAACI group was lower than that in the control group (P＜0.05).The frequencies of CT+TT genetype and T allelic gene in the LAACI group were much higher than those in the control group (P＜0.05);the Logistic regression analysis found that smoking,hypertension,systolic pressure,diastolic pressure,blood glucose level,Lp (a),ox-HDL level,MDA level,NADPH oxiolase activity and NADPH C242T genotype were independent risk factors for LAACI.Conclusion NADPH oxidase P22phox C242T gene polymorphism has a correlation with LAACI and is another independent risk factor for LAACI except for hypertension,smoking and lipid oxidation.
