Effect analysis of indometacin for preventing pancreatitis after ERCP surgery in patients with common bile duct stones
10.3969/j.issn.1671-8348.2018.09.020
- VernacularTitle:吲哚美辛预防老年胆总管结石患者ERCP术后胰腺炎的疗效分析
- Author:
Yueli CHEN
1
;
Jianguo ZHANG
;
Zhaoyue WANG
Author Information
1. 航空总医院消化内科
- Keywords:
indomethacin;
choledocholithiasis;
endoscopic retrograde cholangiopancreatography;
pancreatitis;
elderly
- From:
Chongqing Medicine
2018;47(9):1212-1214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of indomethacin in pancreatitis after endoscopic retrograde cholan-giopancreatography(ERCP)in the patients with choledocholithiasis.Methods Ninety elderly patients with choledocholithiasis were divided into the observation group and control group according to the random number table method,45 cases in each group.The two groups received the therapy of conventional ERCP scheme.The control group used diazepam,pethidine and anisodamine before op-eration.The observation group was preoperatively added with indomethacin on the basis of the control group.The therapeutic effects were analyzed and compared between the two groups.Results The number of intraoperative gastric peristalsis and operation time in the observation group were significantly lower than those in the control group(P<0.05).The level of serum amylase at postoperative 6,24 h in the observation group was significantly lower than that in the control group(P<0.05).The level of serum CRP and MMP-9 at postoperative 24 h in the observation group was significantly lower than that in the control group(P<0.05). The incidence rates of pancreatitis and hyperamylasemia in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Indomethacin can effectively reduce the number of intraoperative gastric peristalsis,postoperative hy-peramylasemia and incidence rate of acute pancreatitis,reduces the level of serum inflammatory factors,and has fewer adverse reac-tions,which is worthy of application.
