Expression of PD-L1 in breast cancer and its correlation with cellular immunity
10.3969/j.issn.1671-8348.2018.09.018
- VernacularTitle:PD-L1在乳腺癌中的表达及其与细胞免疫的相关性分析
- Author:
Lidong WANG
1
;
Weiguo XU
;
Xin YANG
;
Ruijie LI
;
Nana CHEN
;
Honghui GUO
;
Yuepeng ZHAO
Author Information
1. 华北理工大学附属医院肿瘤外科
- Keywords:
breast cancer;
PD-L1;
cellular immunity
- From:
Chongqing Medicine
2018;47(9):1207-1209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of PD-L1 in breast cancer tissue and to investigate its correlation with cellu-lar immunity.Methods One hundred and fourteen paraffin-embedded specimens of breast cancer were collected from the Qian′an Municipal People′s Hospital.The expression of PD-L1 in breast tumor tissue was detected by immunohitochemical technique,then the relationship between PD-L1 expression and tumor clinicopathological characteristics was analyzed;the levels of peripheral blood CD3+,CD3+CD4+,CD3+CD8+,CD3-CD19+,CD3-CD16+CD56+cells and CD4+/CD8+in the patients with PD-L1 negative and PD-L1 positive of the two groups were detected by the flow cytometry.Results Among 114 cases of breast cancer specimen,35 ca-ses(30.7%)were PD-L1 expression positive with the expression rate of 30.7%.The PD-L1 expression was correlated with the tumor size,histological grade and Ki-67 high expression(P<0.05);the cellular immunity status in the patients with PD-L1 negative expression was better than that in the patients with PD-L1 positive expression(P<0.05).Conclusion The PD-L1 expression is closely correlated with the poorer clinicopathological characteristics of breast cancer,its mechanism may be correlated with the dis-ruption of cellular immunity in the patients with PD-L1 positive expression.
