Clinical analysis of aprepitant for treating vomiting caused by cis-platin regimen
10.3969/j.issn.1671-8348.2018.09.014
- VernacularTitle:阿瑞匹坦治疗顺铂方案化疗引起的呕吐临床分析
- Author:
Erhua YAO
1
;
Yinyan ZHENG
;
Lianxing LIN
;
Hecheng HUANG
;
Ping LIANG
;
Fasheng WU
;
Jiayi LIU
Author Information
1. 中山大学附属汕头医院/汕头市中心医院肿瘤放疗科
- Keywords:
aprepitant;
cisplatin;
drug therapy;
postoperative nausea and vomiting;
5-HT3 receptor antagonist;
treatment out-come
- From:
Chongqing Medicine
2018;47(9):1194-1196,1199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of aprepitant in the treatment of cisplatin based chemotherapy in-duced nausea and vomiting.Methods The tumor patients treated with cisplatin(80 mg/m2)chemotherapeutic regimen in Affiliated Shantou Hospital of Sun Yat-Sen University from December 1,2014 to December 1,2016 were selected,61 cases still had vomiting after using granisetron and dexamethasone for routinely stopping vomiting,the patients with aprepitant and dexamethasone for fur-ther stopping vomiting served as the aprepitant group,while the patients with granisetron and dexamethasone as the granisetron group.Then the complete response(CR)rates within 24,24-72,>72-144 h were observed in the two groups.Results The CR rates within 24 h in the aprepitant group and granisetron group were 66.67% and 51.61% respectively,the difference was not sta-tistically significant(P=0.232),which at 24-72 h were 80.00% and 54.84% respectively,the aprepitant group was significantly better than the granisetron group(P=0.036),which at >72-144 h were 86.67% and 64.52% respectively,the aprepitant group was better than the granisetron group(P=0.045).The comparison of adverse reactions between the two antiemetic drugs found that constipation,diarrhea,urticaria,fatigue and anxiety had no significant difference(P>0.05),the occurrence rate of total adverse reactions in the aprepitant group was 23.33%,which in the granisetron group was 25.81%,the difference between the two groups was not statistically significant(P>0.05).Conclusion Aprepitant combined with dexamethasone has better effect for treating hy-peremetic chemotherapy drug cisplatin chemotherapy caused nausea and vomiting with good tolerance.
