Application of magnetic resonance diffusion tensor imaging in rat C 6 glioma grading
10.3969/j.issn.1671-8348.2018.09.001
- VernacularTitle:磁共振扩散张量成像在大鼠C6脑胶质瘤分级中的应用研究
- Author:
Xiangying LI
1
;
Xili JIANG
;
Guang YANG
;
Jianqiang CHEN
;
Yuefu ZHAN
;
Shaohu TANG
;
Xiangjun HAN
Author Information
1. 中南大学湘雅医学院附属海口医院/海口市人民医院放射科
- Keywords:
rat;
glioma;
diffusion tensor imaging;
fractional anisotropy;
rat;
Wistar
- From:
Chongqing Medicine
2018;47(9):1153-1154,1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of fractional anisotropy(FA)values of magnetic resonance diffusion tensor imaging(DTI)parameters in rat rat glioma grading.Methods Sixty-seven female Wistar rats were divided into the experi-mental group(n=57)and control group(n=10)according to the random number table method.All the surviving rats were exam-ined by 3.0T DTI at 1-2 weeks(22 cases)and 3-4 weeks(35 cases)after inoculation,and the FA values of the tumor were ob-tained and compared with the pathological results.Results Among 57 tumor-loading rats,there were 18 low-grade gliomas and 39 high-grade gliomas.DTI showed that the FA value of high-grade gliomas was higher than that of the low-grade glioma,the differ-ence was statistically significant[(0.167 ± 0.035)vs.(0.147 ± 0.015),t=2.34,P<0.05].Conclusion The FA value of DTI pa-rameters can provide accurate,reliable and noninvasive imaging information for preoperative glioma grading.
