Clinical significance of liquid-based cytology and cell paraffin blocks combined with immunocytochemistry in cytopathologic diagnosis of hydrothorax and ascites
10.3969/j.issn.1671-8348.2018.08.015
- VernacularTitle:液基细胞学及细胞蜡块联合免疫细胞化学检测在胸腹水细胞病理诊断中的临床价值
- Author:
Chunling FU
1
;
Dingrong LIU
;
Tong WU
;
Huijie WEI
;
Shiqiong ZHANG
;
Wei LI
;
Jing FANG
;
Yan YANG
;
Feng LIU
Author Information
1. 重庆市涪陵中心医院病理科 408000
- Keywords:
hydrothorax;
ascites;
liquid based cytology;
cell paraffin block;
immunocytochemistry
- From:
Chongqing Medicine
2018;47(8):1058-1060
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of liquid-based cytology and cell paraffin blocks combined with immu-nocytochemical examination in cytopathologic diagnosis of hydrothorax and ascites.Methods One hundred and fourteen cases of hydrothorax and ascites sample were collected.The detection positive rates were compared between the liquid-based cytology and cell paraffin blocks combined with immunocyochemical examination.The suspected positive and positive cases were performed the immunocytochemical examination for further judging benign and malignancy and histological source.Results 114 cases of hydro-thorax and ascites samples,36 cases(31.58%)of positive were diagnosed by liquid-based cytologyamong and 55 cases(48.24%)of positive were diagnosed by cell paraffin blocks combined with immunocytochemical examination,the difference was statistically sig-nificant(P<0.01).There were 55 cases of malignant hydrothorax and ascites,45 cases were hydrothorax and 10 cases were ascites, in hydrothorax,there were 32 cases of lung adenocarcinoma,3 cases of small cell lung cancer,4 cases of breast cancer,1 case of en-dometrial carcinoma,1 case of lymphatic hematopoietic system tumor and 4 cases of unknown origin;in ascites,there were 2 cases of ovarian cancer,1 case of digestive system tumor,1 case of endometrial cancer,1 case of lymphatic hematopoietic system tumor and 5 cases of unknown origin.Conclusion The cell paraffin blocks combined with immunocytochemistry can significantly improve the positive detection rate of hydrothorax and ascites,and helps to judge the source of tissue.
