Genetic polymorphisms of CYP2C9 and VKORC1 among Han population in Yunnan area
10.3969/j.issn.1671-8348.2018.08.013
- VernacularTitle:云南地区汉族人群CYP2C9和VKORC1基因多态性研究
- Author:
Xiaoli ZHAO
1
;
Qionghua SHI
;
Hongwei HUANG
;
Jing QIAN
;
Jianchun SHAO
;
Haisheng LI
;
Yuelin YANG
;
Jun CHEN
;
Dachun HU
Author Information
1. 云南省昆明市第一人民医院/昆明医科大学附属甘美医院检验科 650011
- Keywords:
Yunnan;
Han nationality;
CYP2C9;
VKORC1;
gene polymorphism
- From:
Chongqing Medicine
2018;47(8):1052-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the frequency distribution of CYP2C9 and VKORC1 gene single nucleotide polymor-phisms in Yunnan Han population.Methods CYP2C9(430C> T,1075A>C and 1080C> G)locus and VKORC1(-1639G> A and 1173C> T)locus gene polymorphisms in 202 samples were detected by adopting electrochemical gene sensor method,and the allele frequencies and genotype frequencies were performed the statistics and the gene polymorphism in relevant populations was an-alyzed.Results Among 202 samples,202 cases(100.0%)were genotype C/C at CYP2C9 * 2 locus,C allele frequency was 100.0%;185 cases(91.6%)were genotype A/A at CYP2C9*3 locus,15 cases(7.4%)were A/C genotype,2 cases(1.0%)were C/C genotype,A allele frequency was 95.3%,C allele frequency was 4.7%;CYP2C9*5 locus genotype C/C was in 202 cases (100.0%),C allele frequency was 100%;VKORC1 -1639G > A locus genotype A/A was in 145 cases(71.8%),57 cases (28.2%)were G/A genotype,A allele frequency was 85.9%,G was 14.1%;1173C> T locus genotype T/T was in 145 cases (71.8%),C/T gene type in 57 cases(28.2%),T allele frequency was 85.9%,and C was 14.1%.Conclusion The distribution of CYP2C9 gene in Yunnan Han population is similar to that in other regions of our country.The VKORC1 gene is different from the foreign population,Chinese Han nationality and partial minority nationalities.
