Correlation between levels of serum 25OHD and PTH with osteoporosis degree in elderly patients with fracture
10.3969/j.issn.1671-8348.2018.06.014
- VernacularTitle:老年骨折患者血清25OHD和PTH水平与骨质疏松程度的相关性
- Author:
Zhi TIAN
1
;
Zhaoxu YANG
;
Jing FAN
;
Guanqing LI
;
Xuyang CAO
;
Qiang REN
Author Information
1. 河北省人民医院骨二科
- Keywords:
25-hydroxy vitamin D;
parathyroid hormone;
aged;
osteoporosis
- From:
Chongqing Medicine
2018;47(6):767-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between.serum 25-hydroxy vitamin D (25OHD) and parathyroid hormone (PTH) with the severity in elderly patients with osteoporosis.Methods A total of 160 patients with fractures treated in this hospital from January 2015 to January 2016 were selected and divided into the normal bone mass group(53 cases),osteopenia group (63 cases) and osteoporosis group(44 cases) according to the bone mineral density (BMD) in the lumbar vertebra 1-4,total hip and femoral neck any position.Then the serum levels of 25OHD,PTH,T value of BMD,serum osteocalcin (BGP) and bone alkaline phosphatase (ALP) were compared among 3 groups.Results The serum PTH detection value had no statistically significant difference among the normal group,osteopenia group and osteoporosis group (P＞0.05).The serum 25OHD level in the normal group was higher than that in the osteopenia group and osteoporosis group (P＜0.05);the serum BGP and.ALP levds in the normal group were significantly lower than those in the osteopenia group and osteoporosis group (P＜0.05).The level of serum 25OHD in the osteopenia group was higher than that in the osteoporosis group (P＜0.05).The level of serum BGP and ALP in the osteopenia group was significantly lower than that in the osteoporosis group (P＜0.05).The BMD value of the lumbar vertebra 1-4,total hip and femoral neck in the normal group was significantly higher than that in the steopenia group and osteoporosis group (P＜0.05).There was a significant positive correlation between serum 25OHD and the BMD value in lumbar vertebra 1-4,total hip joint and femoral neck (P＜0.05).Conclusion The level of serum 25OHD is significantly decreased in the patients with osteoporosis,and.is positively correlated with the BMD level.
