Comparison of effects of three different doses of letrozole on ovulation induction and pregnancy situation
10.3969/j.issn.1671-8348.2018.06.010
- VernacularTitle:3种不同剂量来曲唑的促排卵效果及妊娠情况比较
- Author:
Bao LIU
1
;
Wenjie SUN
;
Yi LIN
;
Lijuan HAO
;
Wenzheng ZHOU
Author Information
1. 重庆市妇幼保健院生殖内分泌科 400013
- Keywords:
letrozole;
ovulation disorder;
ovulation induction;
pregnancy
- From:
Chongqing Medicine
2018;47(6):753-755
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of three different doses of letrozole(LE) on the promoting ovulation and pregnancy situation.Methods A total of 92 infertility patients with type Ⅱ ovulation disorder in this hospital from January 2013 to December 2014 were divided into three groups.The first group and second group were respectively given LE 2.5 mg/d and 5.0 mg/d from 3 d of menses for 5 d.The third group took LE 20 mg at draught on 3 d of menses.On the HCG injection day,follicle maturity time,number of mature follicles,ovulation rate,luteinized unrupture follicle syndrome (LUFS) and pregnancy rate were observed.Results The follicle maturity time,number of mature follicles,ovulation rate and clinical pregnancy rate on HCG injection day had no statistically significant difference among the three groups (P＞0.05).The incidence of LUFS had statistically significant difference(P＜0.05).Conclusion The promoting ovulation effect and clinical pregnancy rate have no difference among 3 different LE doses,but the occurrence rate of luteinized unruptured follicle syndrome(LUFS) in the 2.5 mg/d group is higher,therefore in the practical work,the medication administration mode may be selected according to the actual situation.
