Value assessment and clinical significance of ALR in early diagnosis of acute kidney injury
10.3969/j.issn.1671-8348.2018.06.007
- VernacularTitle:ALR在急性肾损伤早期诊断中的价值评估及临床意义
- Author:
Yuan TIAN
1
;
Ling ZHANG
;
Yuanyuan SU
;
An ZHANG
;
Ling ZHONG
;
Shuqin XIE
;
Xiaohui LIAO
Author Information
1. 重庆医科大学附属第二医院肾内科 400010
- Keywords:
augmenter of liver regeneration;
acute kidney injury;
biomarker
- From:
Chongqing Medicine
2018;47(6):744-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether augmenter of liver regeneration (ALR) can serve as early diagnostic biomarker in the patients with acute kidney injury(AKI).Methods The inpatients with possibility to AKI in the central ICU of Second Affiliated Hospital of Chongqing Medical University from October 2014 to October 2015 were recruited and assigned to the AKI group and non-AKI group according to the KDIGO guidance.Blood and urine ALR and blood creatinine were detected at 0,6,12,24,48,72 h after entering the group.Results Among all cases,40 cases(62.5％) developed to AKI.Blood ALR and urine ALR at 6h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),the blood and urine ALR levels reached to the peak value at 12,24 h after entering the group;the blood creatinine level at 12 h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),blood creatinine level was still slowly and progressively elevated at 72 h after entering the group.Conclusion Serum and urine ALR levels are significantly increased in the early stage of AKI,which indicates that ALR may be a new type biomarker for diagnosing AKI.
