Effects of naringin on hemodynamics in myocardial ischemia-reperfusion injury rats
10.3969/j.issn.1671-8348.2018.06.004
- VernacularTitle:柚皮苷对心肌缺血-再灌注损伤大鼠血流动力学的影响
- Author:
Dan LIU
1
,
2
;
Liangyong JIN
;
Xiaoling FENG
;
Xiaoshan LI
;
Yonghui ZHANG
Author Information
1. 重庆三峡医药高等专科学校 404120
2. 重庆市抗肿瘤天然药物工程技术研究中心 404120
- Keywords:
naringin;
myocardial ischemia-reperfusion injury;
hemodynamic
- From:
Chongqing Medicine
2018;47(6):733-735,739
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of naringin (Nar) on hemodynamics in myocardial ischemia-reperfusion(MI/R) injury rats for investigating its protective role on MI/R rats.Methods The ischemia-reperfusion(I/R) model was prepared by ligating the left anterior descending coronary artery,meanwhile different doses of Nar(10,20,40 mg/kg) were given.Then the electrocardiogram (ECG) was recorded after 7 d.The left ventricular end diastolic pressure (LVEDP),left ventricular systolic pressure (LVSP) and maximum ascending rate of left ventricular pressure/maximal descending rate of left ventricular pressure (±dp/dtmax) were measured.The activities of srum creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by using the chemical colorimetry method.Results Compared with the MI/R group,Nar 20,40 mg/kg could decrease LVEDP,increased ±dp/ dtmax and LVSP,and decreased the activities of serum CK and LDH (P＜0.05),showing a dose-dependent manner.Conclusion Nar has the protective effect against MI/R injury rat and alleviates the myocardial damage extent,which may be related with improving the hemodynamics.
