Influence of folic acid and vitamin B12 levels on curative effect in Uygur and Han patients with non-small ceil lung cancer treated by pemetrexed combine with platinum chemotherapy
10.3969/j.issn.1671-8348.2018.05.019
- VernacularTitle:叶酸及维生素B12水平对培美曲塞联合铂类化疗的维汉两族NSCLC患者疗效的影响
- Author:
Fei TENG
1
;
Chenlu MA
;
Jianjun LI
;
Li SHAN
Author Information
1. 新疆医科大学研究生学院
- Keywords:
carcinoma,non-small-cell lung;
folic acid;
vitamin B12;
pemetrexed
- From:
Chongqing Medicine
2018;47(5):638-641
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of folic acid and vitamin B12 levels on the curative effect in Uygur and Han patients with non-small cell lung cancer(NSCLC) treated by first-line chemotherapy of pemetrexed combine with platinum.Methods Sixty-one Uygur and Han cases of NSCLC treated by the first-line chemotherapy of pemetrexed combine with platinum and at least two cycles of this regimen were selected.The folic acid and vitamin B12 levels before chemotherapy were detected by using the electrochemiluminescence method.The chemotherapeutic effect evaluation was performed once at least per 2 weeks.The follow up lasted until the disease progress or first line chemotherapy finish,furthermore the data collected from the two nationalities were performed the comparative analysis.Results The gender,smoking history,age,differentiation degree,staging and vitamin B12 level had no statistical differences between Uygur and Han NSCLC patients(P＞0.05);but the serum folic acid level in Han NSCLC patients was higher than that in Uygur NSCLC patients(P＜0.05).The gender,smoking history,age,tumor differentiation degree,neoplasm staging and serum vitamin B12 level had no influence on the prognosis in NSCLC patients using the pemetrexed combine with platinum chemotherapy(P＞0.05),while the prognosis in Han patients was better than that in Uygur patients(P＜0.05),and the patients with higher folic acid level had good prognosis.The progress free survival(PFS) in Han NSCLC patients was obviously superior to that in Uygur patients.Conclusion The serum folic acid level in Han NSCLC patients is higher than that in Uygur patients,and the curative effect in Han patients receiving the pemetrexed combine with platinum chemotherapy is obviously superior to that in Uygur patients,and serum folic acid level may be related with the prognosis in NSCLC patients.
