Clinical analysis on platinum-based combined chemotherapeutical regimens for treating relapsed or refractory non-Hodgkin lymphoma
10.3969/j.issn.1671-8348.2018.05.013
- VernacularTitle:含铂类联合方案治疗复发或难治性NHL的临床分析
- Author:
Hongxue WANG
1
;
Meilin CHEN
;
Fanghui QIN
;
Wenxian ZHOU
;
Yuxian JIA
;
Jun CHEN
;
Hong CEN
;
Yu'an XIE
;
Yongkui LU
;
Weimin XIE
Author Information
1. 广西医科大学附属肿瘤医院化疗五科
- Keywords:
lymphoma,non-Hodgkin;
relapse;
refractory;
platinum;
drug therapy,combination
- From:
Chongqing Medicine
2018;47(5):618-621,625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and adverse reactions of platinum-based combined chemotherapeutical regimens in treating relapsed or refractory non-Hodgkin lymphoma(NHL).Methods The clinical data of 68 patients with relapsed or refractory NHL treated with platinum-based combined chemotherapeutical regimens in the Affiliated Tumor Hospital of Guangxi Medical University from January 2008 to December 2014 were retrospectively analyzed.The curative effect of related regimens,adverse reactions and related influence factors were analyzed.Results Sixty-eight cases received 283 cycles of chemotherapy.In all cases,11 cases(16.18 ％) achieved the complete response(CR),31 cases(45.59 ％) achieved the partial response(PR),the overall response rate(ORR) was 61.76％;the median progression-free survival(PFS) was 6.51 months(95％CI:4.97-8.04 months).ORR and PFS in the cases of stage Ⅱ-Ⅲ,IPI score 0-2 and receiving only one chemotherapeutical regimen were superior to those in the cases of corresponding subgroup(P＜0.05);ORR and PFS had no statistical difference between the B cells lymphoma and Tcells lymphoma(P＞0.05).The medion PFS in the combined R group was 11.16 months,which was longer than 5.84 months in the non-combined R group(P =0.004).The major adverse events (stage Ⅱ-Ⅲ) included leukopenia (41.18 ％),thrombocytopenia (27.94％),hemoglobin decrease(11.76％),vomiting(8.82％) and diarrhea(1.47％).Conclusion The platinum-based combined chemotherapeutical regimens are effective with good safety in the treatment of relapsed or refractory NHL.
