Simultaneous use of budesonide and formoterol in asthma control and relieving therapy:a Meta analysis
10.3969/j.issn.1671-8348.2018.04.023
- VernacularTitle:布地奈德与福莫特罗同时用于哮喘控制和缓解治疗的Meta分析
- Author:
Yehong XIE
1
;
Xiaoqin LU
;
Zhi DONG
Author Information
1. 重庆医科大学药学院 400016
- Keywords:
asthma;
budesonide;
formoterol;
Meta analysis
- From:
Chongqing Medicine
2018;47(4):512-515,518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically assess the effectiveness and safety of simultaneously using budesonide(BUD) and formoterol(FORM) in asthma control and relieving therapy.Methods The databases including PubMed,Cochrane Library,EM-base,VIP,CNKI,CBM,Wanfang Data Knowledge Service Platform Database were retrieved by computer.The randomized controlled trials(RCTs) about BUD and FORM simultaneous use in asthma control and relieving therapy(observation group),BUD and FORM use in asthma control and terbutaline(TER) use in relieving therapy were collected in the various databases from their establishment to May 2017.The meta analysis was conducted by adopting the RevMan 5.3 software.Results A total of 5 RCTs(6 control groups) involving 10158 patients were included.The observation group was lower than the control group in the aspects of asthma aggravation admission or emergency person-times(OR=0.70,95％CI:0.59-0.85,P＜0.01),occurrence rate of serious adverse events(OR=0.66,95％CI:0.52-0.82,P＜0.01),occurrence rate of experiment termination by various causes[OR=0.84,95％CI:0.73-0.96,P=0.01);compared with the observation group,the improvement of night PEF value and FEV1 value after treatment in the control group was more significant (MD=4.05,95 ％ CI:0.18-7.93,P =0.04;MD =0.04,95 ％ CI:0.03-0.05,P＜0.01);the number of nocturnal awakening decrease times and occurrence rate of fatal adverse events had no statistically significant difference between the two groups[OR=1.25,95％CI:1.00-1.56,P=0.05;OR=1.01,95％CI:0.23-4.45,P=0.99).Conclusion BUD and FORM simultaneous use in asthma control and relieving therapy has an advantage in the aspects of reducing asthma acute attack and safety;BUD and FORM is used in asthma control,while TER is used in relieving therapy and has better effect for improving the lung function.
