Effect of RBP4 on neurocognitive function in diabetic nephropathy with silent cerebral infarction
10.3969/j.issn.1671-8348.2018.04.012
- VernacularTitle:RBP4对糖尿病肾病无症状脑梗死神经认知功能的影响
- Author:
Danyan CHEN
1
;
Xiaolong HUANG
;
Song LU
;
Huacong DENG
;
Hua GAN
;
Xiaogang DU
;
Chengjian WANG
;
Rongxi HUANG
;
Binghan ZHANG
Author Information
1. 重庆市人民医院中山院区内分泌肾内科
- Keywords:
diabetic nephropathies;
silent cerebral infarction;
retinol binding protein4;
function impairment;
lipoprotein-associated phospholipase A2;
receptors,CXCR4
- From:
Chongqing Medicine
2018;47(4):473-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impairment effect of retinol binding protein 4(RBP4) on neurocognitive function in diabetic nephropathy(DN) patients with silent cerebral infarction(SCI) and to explore its mechanism.Methods Sixty patients with newly diagnosed DN and 30 healthy volunteers were selected as the study subjects and the DN cases were divided into the complicating SCI group(SCI,n=30) and non-complicating SCI group(NSCI,n=30) according to the imaging results.The degrees of neurological function deficit and Montreal cognitive assessment(MoCA) were evaluated.Serum RBP4 level was determined by ELISA and expressions of Lp-PLA2 and C-X-C chemokine receptor type 4(CXCR4) were determined by Western blot.Results Compared with the NSCI group,the neurocognitive function in the SCI group was subsided,the expression levels of RBP4,Lp-PLA2 and CXCR4 were increased(P＜0.05).The RBP4 level was positively correlated with the neurocognitive function impairment in SCI patients,moreover,there existed a regression correlation between them.Conclusion Serum RBP4 may serve as the predictive factor of DN complicating SCI and is positively correlated with neurocognitive dysfunction.Lp-PLA2/CXCR4 pathway activation may be one of its pathogenesis.
