Effects of glycyrrhizin on alcoholic fatty liver cells incluced in vitro and its mechanism
10.3969/j.issn.1671-8348.2018.04.002
- VernacularTitle:甘草甜素对体外诱导的酒精性脂肪肝细胞的影响及机制研究
- Author:
Xiaofen BU
1
;
Jun LI
;
Hong ZHU
Author Information
1. 华中科技大学同济医学院附属武汉中心医院综合二科
- Keywords:
glycyrrhizin;
triglyceride;
fatty liver,alcoholic;
alanine transaminase;
aspartate aminotransferase
- From:
Chongqing Medicine
2018;47(4):436-438,445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glycyrrhizin on the cell model of alcoholic fatty liver(AFL) induced in vitro and its possible mechanism.Methods The in vitro induced AFL cells were divided into the control group,separating ethanol group,glycyrrhizin group and continuous induction group.The levels of intracellular triglyceride(TG) and leakage amounts of ALT and AST,cell cycle change and protein and mRNA expressions of PPAR-γ,SREBP-1 and SCAP were measured.Results Glycyrrhizin could obviously reduce the apoptosis occurrence;compared with the control group,the level of intracellular TG and the leakage amounts of ALT and AST,and the protein and mRNA expressions of PPAR-γ,SREBP-1 and SCAP were significantly decreased(P＜0.05).Conclusion Glycyrrhizin may alleviate the fat change of in vitro induced AFL cells by down-regulating expressions of PPAR-γ,SREBP-1 and SCAP.
