Analysis on 4 cases of polycythemia vera transforming to acute myeloid leukemia

VernacularTitle:真性红细胞增多症急性髓细胞白血病转化4例分析
Author: Xiupeng YE ¹ ; Shen BAO ; Yuping WEI ; Feng ZHI ; Ying GUO ; Yeqiong LI ; Lijun SONG ; Yujie NIU ; Yue SUN
Author Information

1. 宁夏回族自治区人民医院/西北民族大学第一附属医院
Keywords: polycythemia vera; leukemia,myeloid,acute; myelofibrosis; osteopetrosis; hydroxyurea
From: Chongqing Medicine 2018;47(3):306-307
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical characteristics,diagnosis and treatment of polycythemia vera(PV) transforming to acute myeloid leukemia(AML).Methods The clinical features and process of diagnosis and treatment in 4 cases of PV transforming to AML were analyzed.Results The case 1 had 10 years history of PV,after experiencing PV,had myelofibrosis and transformed to AML at the end stage of natural disease course;the case 2 had 7 years history of PV,orally took hydroxyurea(HU) treatment in recent 2 years and transformed to AML at present,his chromosome karyotype analysis showed 46,XY,del(7)(q31q36),del (18) (q22)[10],which was considered as treatment-related AML;the case 3 and 4 orally took H U for a long time after diagnosing HU,and respectively turned into AML during the pathologic polyemia stage after 6 and 7 years.Conclusion PV can be transformed to AML,the safety of HU in treatment should by paid attention to.