Influence of γ-H2AX expression on prognosis in patients with newly diagnosed multiple myeloma
10.3969/j.issn.1671-8348.2018.03.002
- VernacularTitle:γ-H2AX的表达对初诊多发性骨髓瘤患者的预后影响
- Author:
Chun CAO
1
;
Li XU
;
Juan FENG
;
Hailong TANG
;
Hongjuan DONG
;
Hongtao GU
;
Mimi SHU
;
Qingxian BAI
;
Rong LIANG
;
Tao ZHANG
;
Lan YANG
;
Baoxia DONG
;
Xiequn CHEN
;
Guangxun GAO
Author Information
1. 第四军医大学第一附属医院血液内科/中国人民解放军血液病专病中心
- Keywords:
multiple myeloma;
DNA breaks,double strand;
immunohistochemistry;
prognosis;
γ-H2AX
- From:
Chongqing Medicine
2018;47(3):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of bone marrow γ-H2AX in the patients with multiple myeloma(MM) and its correlation with the prognosis.Methods The patients with newly diagnosed MM in this hospital were selected as the case group,and the patients with non-hemopoietic system tumor without obvious morphological abnormalities by bone marrow smear and biopsy served as the control group.The immunohistochemistry was adopted to detect the expression level of bone marrow γ-H2AX in the cases group and control group,the image-Pro Plus(IPP) semiquantitative analysis was performed.The expression differences were compared between the two groups,moreover the case group was re-divided into the strong expression group and weak expression group according to γ-H2AX expression level.Then the relation ship between γ-H2AX expression level and the prognosis in the patients with MM.Results The bone marrow γ-H2AX expression level in the case group was significantly higher than that in the control group (P＜0.05);the level of γ-H2AX expression in the strong expression group was significantly stronger than that in the weak expression group (P＜0.05).Conclusion The level of γ-H2AX expression was higher among MM patients,and the over expression of γ-H2AX predicts the shorter survival time.
