Clinical study on RunX2 expression in bone giant cell tumor and its regulation on bone
10.3969/j.issn.1671-8348.2018.02.011
- VernacularTitle:骨巨细胞瘤中RunX2表达及对骨质调控的临床研究
- Author:
Guowei LI
1
;
Yuanqing GUO
;
Tao CHEN
;
Kuibo ZHANG
;
Dawei ZHANG
;
Bing YU
;
Rongkai ZHANG
Author Information
1. 中山大学附属第五医院脊柱外科
- Keywords:
core binding factors;
giant cell tumor of bone;
bone resorption
- From:
Chongqing Medicine
2018;47(2):180-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the RunX2 expression and the clinicopathological features in bone giant cell tumor(GCT).Methods Fifty-eight specimens of GCT were selected and grouped according to the malignant degree,tumor pathological grade,whether having soft tissue invasion and complicating pathological fracture.Then the immunohistochemical staining technique was used to analyze and compare the difference of RunX2 expression levels among different groups.Results The RunX2 expression level in malignant GCT tissues was significantly higher than that in benign GCT tissue(P＜0.05).RunX2 expression level was increased with the GCT tissue histological grade increase(P＜0.05).The expression level RunX2 in GCT tissue with soft tissue invasion was significantly higher than that in the GCT tissue without invasion(P＜0.05);the RunX2 expression level in GCT tissue with complicating pathologic fractures was significantly higher than that in the GCT tissue without complicating pathologic fractures(P＜0.05).Conclusion The RunX2 expression level is related to the severity of GCT.
