Expression of CXCL10 ,CXCR3 and T cell subsets in peripheral blood and effect of compound Chinese medicine on it in patients with advanced vitiligo
10.3969/j.issn.1671-8348.2018.02.006
- VernacularTitle:CXCL10、CXCR3及T细胞亚群在进展期白癜风患者外周血中的表达及复方中药对其影响
- Author:
Li DENG
1
,
2
;
Xue JIANG
;
Yuyi WANG
;
Bingjun SHI
;
Yang LIU
;
Wei XU
;
Qingchun DIAO
;
Wenhao ZHENG
Author Information
1. 重庆市中医院/重庆市第一人民医院皮肤科 400000
2. 西南医科大学附属医院皮肤科
- Keywords:
vitiligo;
drugs,chinese herbal;
chemokine CXCL10;
receptors,CXCR3;
T-lymphocyte subsets
- From:
Chongqing Medicine
2018;47(2):164-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression levels of peripheral blood CXCL10 and its receptor CXCR3 and T cell subsets in of the patients with advanced vitiligo and the influence of compound Chinese medicine on it.Methods Flow cytometry was used to detect the cellular proportions of peripheral blood T cell subsets,ELISA was employed to quantify serum CXCL10 and CXCR3 expression levels before and after treatment.Results After 1 month of taking Chinese medicine,the proportions of CD3+ CD4+ cells and CD3+ CD8+ cells were increased compared before treatment(P＜0.05).The expression level of peripheral serum CXCL10 before treatment was significantly increased compare with the healthy control group(P＜0.01),and the CXCL10 level after treatment was decreased significantly compared with that before treatment(P＜0.05).The expression level of peripheral serum CXCR3 was significantly increased compared with the healthy control group(P＜0.05),while which after treatment was still significantly higher than that in the healthy control group(P＜0.05).Conclusion CXCL10,CXCR3 and T cell subsets proportion may be involved in the pathogenesis of vitiligo.The compound Chinese medicine used in this study plays the curative effect possibly by regulating T cell subsets and expression levels of CXCL10 and CXCR3.
