Expression of HOXB7 protein in colorectal cancer and its clinical significance
10.3969/j.issn.1671-8348.2018.01.021
- VernacularTitle:结直肠癌组织中同源异型盒基因B7蛋白的表达及临床意义
- Author:
Yunchun LUO
1
;
Wen YI
;
Yuzhou YAO
;
Ni ZHU
;
Pengfei QIN
Author Information
1. 湖北省宜昌市中心人民医院 443000
- Keywords:
colorectal neolpasms;
homeodomain proteins;
neoplasm metastasis;
prognosis
- From:
Chongqing Medicine
2018;47(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HOXB7 in colorectal cancer and its relationship with clinicopathological factors and prognosis.Methods Eighty-seven patients with colorectal cancer were retrospectively analyzed.The expression of HOXB7 mRNA and protein in colorectal cancer tissues was detected by RT-PCR and immunohistochemical methods.Their correlation with clinicopathological parameters and prognosis was analyzed.Results The relative expression level of HOXB7 mRNA in colorectal cancer tissue was(42.4 ± 16.3),which was significantly higher than(19.4 ± 7.6) in the paracancerous normal tissue(P＜0.05).The positive expression rate of HOXB7 protein in colorectal cancer tissues was 73.9％,which was obviously higher than 10.3 ％ in the paracancerous normal tissue (P＜ 0.05);expression of HOXB7 protein was significantly correlated with the TNM stage,lymph node metastasis and distant metastasis(P＜0.05),moreover the patients with HOXB7 positive expression had poorer prognosis.Conclusion HOXB7 protein expression is up-regulated in colorectal cancer tissue,and its high expression is correlated with the clinicopathological factors and prognosis in the patients with colorectal cancer.
